Pediatric Cardiovascular Research and Innovation

We support groundbreaking research and innovation geared toward driving improvements in care and outcomes, and developing new therapies for the next generation.

Why participate in research?

Research allows us to understand the best treatments for children with heart disease today, and to develop new therapies to help children impacted by heart disease in the future.

Some of the benefits of research include:

  • Enrollment in a research study may allow access to new drugs, treatments, or monitoring being studied to see if they work better than current therapies
  • Determining the best treatments specifically for children rather than extrapolating information from adults that may not apply
  • Understanding the best dose of medications for children to prevent harmful side effects or under-treatment
  • Developing devices sized for children
  • Understanding the impact of treatments on a child’s long-term outcomes, growth, and development

For more information, visit

Michigan Congenital Heart Outcomes Research and Discovery (M-CHORD) Program

M-CHORD is our unique research core within the Congenital Heart Center fully dedicated to supporting pediatric and congenital cardiovascular research.  The expertise of our faculty and staff spans the spectrum of clinical investigation including translational research, clinical trials of new drugs and devices, outcomes and health services research, and multicenter collaborative quality improvement. Our investigators are highly productive publishing more than 170 scientific manuscripts each year, supported by more than 50 active research grants.

For more information, please contact Dr. Sara Pasquali or Dr. Caren Goldberg.

Pediatric Heart Network Core Site

Pediatric Heart Network

We are one of nine centers across the country selected to participate in the Pediatric Heart Network (PHN), funded by the National Heart, Lung, and Blood Institute. Through this network, our patients have access to clinical trials of cutting-edge therapies and interventions.

The PHN Single Ventricle Reconstruction Trial, led by U-M Congenital Heart Center investigators, was the first multi-center congenital heart surgery randomized trial ever accomplished. U-M Congenital Heart Center investigators also lead the PHN biorepository, PHN Integrated CARdiac Data and Outcomes (iCARD) Collaborative, and numerous other PHN efforts

Novel devices and therapies

We lead the development and testing of novel devices and treatments tailored toward the pediatric heart population. 

Examples include:

  • 3-D airway splints
3d printed airway splints
3-D printed airway splints

As reported in the New England Journal of Medicine, we have developed and implanted the first bioresorbable airway splints created using 3-D printing technology. These splints have been implanted in more than 25 patients to date to treat life-threatening airway narrowing many of whom are impacted by congenital heart disease.

  • 3D Visualization Technologies

Our heart center is developing unique ways of utilizing virtual and printed 3D models to prepare for and even guide cardiac surgery and transcatheter interventions.  We have also teamed up with other U-M experts to advance the use of computational fluid dynamics to help predict procedural outcomes in our patients.

  • Donor heart preservation technology

Our investigators are developing technology to allow prolonged perfusion of donor hearts with the aim of improving organ availability and viability for heart pediatric transplant.

  • Regenerative medicine

Our team is leading studies exploring new treatments for children with heart failure through the use of stem cells and tissue engineering.

Connecting data across the country to enable more discoveries, faster improvement

Cardiac Networks United

We lead data coordinating center activities for Cardiac Networks United, which integrates several large networks spanning in total more than two-thirds of the nation’s congenital heart programs. These initiatives bring multiple data sources and expertise together to drive novel research otherwise not possible, and translate discovery to the bedside across hospitals to improve outcomes.



Understanding congenital heart disease quality and costs

Our investigators lead national efforts geared toward understanding quality of congenital heart care, investigating variation in quality and costs of care across centers, and designing initiatives to reduce this variation and improve care and outcomes.


Precision Medicine

Through multiple lines of investigation, we aim to study and develop more individualized strategies for prevention, recognition, and treatment of adverse events tailored to the specific traits and needs of each heart patient. 


Improving Outcomes Across the Lifespan

We are one of the first programs in the country to systematically track long-term survival, morbidities, and quality of life for children undergoing heart surgery at our center, regardless of where they live or receive follow-up care. We have developed a novel “patient-reported outcomes” portal that will drive a better understanding of these critical outcomes, conduct numerous studies geared toward optimizing neurodevelopment, and have recently initiated a new program focused on expanding psychosocial care and research.